Cellular machinery to fuse antimicrobial autophagosome with lysosome
نویسندگان
چکیده
منابع مشابه
New insights into autophagosome-lysosome fusion.
Macroautophagy (autophagy) is a highly conserved intracellular degradation system that is essential for homeostasis in eukaryotic cells. Due to the wide variety of the cytoplasmic targets of autophagy, its dysregulation is associated with many diseases in humans, such as neurodegenerative diseases, heart disease and cancer. During autophagy, cytoplasmic materials are sequestered by the autophag...
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H.-G. Wang (ed.), Autophagy and Cancer, Current Cancer Research 8, DOI 10.1007/978-1-4614-6561-4_2, © Springer Science+Business Media, LLC 2013 Abstract Autophagy is a conserved cytoplasmic process from yeast to mammals, by which cells degrade and recycle their intracellular components. During macroautophagy, a unique compartment, named the autophagosome, is formed to engulf the cargos and send...
متن کاملAutophagosome–lysosome fusion is independent of V-ATPase-mediated acidification
The ATP-dependent proton pump V-ATPase ensures low intralysosomal pH, which is essential for lysosomal hydrolase activity. Based on studies with the V-ATPase inhibitor BafilomycinA1, lysosomal acidification is also thought to be required for fusion with incoming vesicles from the autophagic and endocytic pathways. Here we show that loss of V-ATPase subunits in the Drosophila fat body causes an ...
متن کاملCell type-specific Rab32 and Rab38 cooperate with the ubiquitous lysosome biogenesis machinery to synthesize specialized lysosome-related organelles
Lysosome-related organelles (LROs) exist in specialized cells to serve specific functions and typically co-exist with conventional lysosomes. The biogenesis of LROs is known to utilize much of the common protein machinery used in the transport of integral membrane proteins to lysosomes. Consequently, an outstanding question in the field has been how specific cargoes are trafficked to LROs inste...
متن کاملAutophagosome-lysosome fusion in neurons requires INPP5E, a protein associated with Joubert syndrome.
Autophagy is a multistep membrane traffic pathway. In contrast to autophagosome formation, the mechanisms underlying autophagosome-lysosome fusion remain largely unknown. Here, we describe a novel autophagy regulator, inositol polyphosphate-5-phosphatase E (INPP5E), involved in autophagosome-lysosome fusion process. In neuronal cells, INPP5E knockdown strongly inhibited autophagy by impairing t...
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ژورنال
عنوان ژورنال: Communicative & Integrative Biology
سال: 2010
ISSN: 1942-0889
DOI: 10.4161/cib.3.4.12030